Antonio Damasio; Descartes' Error
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Damasio; Descartes' Error 3 Phineas P. Gage, 1848, 25 years old, railroad foreman, VT, drill hole, explosive powder, iron rod; went through his skull, front of the brain, survived, personality changed.
Damasio; Descartes' Error 27 Brodmann's areas - (diagram) 24
Damasio; Descartes' Error 28 Limbic system, a catchall for a number of evolutionarily old structures, many neuroscientists resist using it. 1
Damasio; Descartes' Error 66 Functions are apportioned asymmetrically to the cerebral hemispheres; one final controller for choosing an action or thought. 38
Damasio; Descartes' Error 66 Language depends largely on left-hemisphere structures in more than 95% of people, including many left-handers. 0
Damasio; Descartes' Error 71 It is proposed that the anterior cingulate cortex is a particular region where systems concerned with emotion, attention, and working memory interact so intimately that they contribute the source for the energy for both external action (movement) and internal action (thought, animation, reasoning). 5
Damasio; Descartes' Error 91 Early visual cortices (V1, V2, V3, V4, V5) - (diagram) 20
Damasio; Descartes' Error 91 V1, primary visual cortex, Brodmann's area 17. 0
Damasio; Descartes' Error 93 Between the brain's five main sensory input sectors and three main output sectors lie the (1) association cortices, (2) basal ganglia, (3) thalamus, (4) limbic system cortices, (5) brain stem, (6) cerebellum. 2
Damasio; Descartes' Error 94 Integrated mind from parcellated activity. 1
Damasio; Descartes' Error 95 Mind integration is created from the concerted action of large-scale systems by synchronizing sets of neural activity in separate brain regions. 1
Damasio; Descartes' Error 96 Each sensory system appears equipped to provide its own local attention and working-memory. For global attention and working memory, the prefrontal cortices and some limbic system structures (anterior cingulate) are essential. 1
Damasio; Descartes' Error 101 Patients with extensive damage to the early visual cortices lose their ability to generate visual images. 5
Damasio; Descartes' Error 101 PET and fMRI studies show that recollection of visual images activates the early visual cortices. 0
Damasio; Descartes' Error 118 Brainstem and hypothalamus circuitry is mostly innate and stable. 17
Damasio; Descartes' Error 118 Limbic system contains both innate circuitry and circuitry modifiable by experience. 0
Damasio; Descartes' Error 120 Small collections of neurons can deliver a dose of dopamine, norepinephrine, serotonin or acetylcholine to widespread regions of the brain including the cerebral cortex and basal ganglia. 2
Damasio; Descartes' Error 122 Massively recurrent circuit arrangements, feedforward and feedback loops; some of the loops are purely chemical. 2
Damasio; Descartes' Error 123 Hypothalamus, brain stem and the limbic system intervene in body regulation and in all neural processes on which mind phenomena are based (perception, learning, recall, emotion, feeling, reasoning, creativity). 1
Damasio; Descartes' Error 123 Body regulation, survival, and mind are intimately interwoven. 0
Damasio; Descartes' Error 132 Primary emotions - (diagram) 9
Damasio; Descartes' Error 134 Secondary emotions involve the prefrontal cortex and the somatosensory cortices as well as structures in the limbic system. 2
Damasio; Descartes' Error 137 Secondary emotions - (diagram) 3
Damasio; Descartes' Error 138 Prefrontal patients can have primary emotions. 1
Damasio; Descartes' Error 139 Limbic system damage in the amygdala or anterior cingulate usually implies a more pervasive impairment of both primary and secondary emotions. 1
Damasio; Descartes' Error 139 Feeling - the experience of all the changes that constitute an emotional response. 0
Damasio; Descartes' Error 139 Damage to limbic system impairs the processing of primary emotion; damage to prefrontal cortices compromises the processing of secondary emotions. 0
Damasio; Descartes' Error 142 Difference between facial expressions of genuine and make-believe emotions. 3
Damasio; Descartes' Error 142 Smiles of real joy and smiles of politeness. 0
Damasio; Descartes' Error 143 What is a feeling? Some feelings relate to emotions; many that do not; all emotions generate feelings. 1
Damasio; Descartes' Error 143 Background feelings - those that do not originate in emotions. 0
Damasio; Descartes' Error 145 Feel and emotion -  (diagram) 2
Damasio; Descartes' Error 150 Background feeling, a body state prevailing between emotions. 5
Damasio; Descartes' Error 150 When we feel happiness, anger, or another emotion, the background feeling has been superseded by an emotional feeling. 0
Damasio; Descartes' Error 159 Feelings are first and foremost about the body, the cognition of our visceral and musculoskeletal state. 9
Damasio; Descartes' Error 159 Body images give to other images a quality of goodness or badness, of pleasure or pain. 0
Damasio; Descartes' Error 160 Chemicals involved in emotions and moods are not enough to explain how we feel. 1
Damasio; Descartes' Error 160 Endorphins are the brains own morphine and can change how we feel about ourselves. 0
Damasio; Descartes' Error 160 Neurotransmitters dopamine, norepinephrine, and serotonin, as well as neuromodulators can also change how we feel about ourselves. 0
Damasio; Descartes' Error 163 Emotion and feeling -  (diagram) 3
Damasio; Descartes' Error 182 Entire prefrontal region seems dedicated to categorizing contingencies. 19
Damasio; Descartes' Error 183 Different domains of knowledge are categorized in different prefrontal regions. 1
Damasio; Descartes' Error 183 Bioregulatory and social domain have affinity for the ventromedial sector. 0
Damasio; Descartes' Error 183 Domains that subsume knowledge of the external world align with the dorsolateral region. 0
Damasio; Descartes' Error 183 Prefrontal cortices are directly connected to every avenue of motor and chemical response available to the brain. 0
Damasio; Descartes' Error 183 Dorsolateral and upper medial sectors can activate the premotor cortices and from there the primary motor cortices, the supplementary motor area, and the third motor area. 0
Damasio; Descartes' Error 183 Subcortical motor machinery of the basal ganglia is accessible to the prefrontal cortices. 0
Damasio; Descartes' Error 183 Ventromedial prefrontal cortices send signals to autonomic nervous system effectors and can promote chemical responses associated with emotion out of the hypothalamus and brain stem. 0
Damasio; Descartes' Error 183 Prefrontal cortices, particularly the ventromedial sector can acquire a three-way link between (1) body state, (2) the individual's unique experience, (3) effectors of those body states. 0
Damasio; Descartes' Error 190 Natural selection works by conserving something that works, selecting other devices that can cope with complexity. 7
Damasio; Descartes' Error 194 Gut feeling 4
Damasio; Descartes' Error