Llinás; I of the Vortex
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Llinás; I of the Vortex 9 Many types of neurons in the nervous system are endowed with particular types of intrinsic electrical activity.
Llinás; I of the Vortex 10 Simultaneity of neuronal activity is the most pervasive mode of operation of the brain.  Neuronal groups that oscillate in phase, i.e. coherently, support simultaneity of activity. 1
Llinás; I of the Vortex 12 Simultaneity of neuronal activity arising from intrinsic oscillatory electrical activity, resonance, and coherence are at the root of cognition. 2
Llinás; I of the Vortex 13 Brain operates as a reality emulator. 1
Llinás; I of the Vortex 17 Nervous systems are an exclusive property of actively moving creatures. 4
Llinás; I of the Vortex 18 Brains are an evolutionary prerequisite for guided movement in primitive animals. 1
Llinás; I of the Vortex 18 Nervous system evolved to provide a plan, one composed of goal-oriented, mostly short-lived prediction verified by moment-to-moment sensory input. 0
Llinás; I of the Vortex 21 Prediction is the ultimate function of the brain. 3
Llinás; I of the Vortex 25 Ability to predict evolved in tandem with increasingly complex movement strategies. 4
Llinás; I of the Vortex 30 Scherzo of Schubert's Piano Quartet No.8 requires repetitive hand movements at approximately 8 Hz, which approaches the upper limit for finger movements by professional pianists. 5
Llinás; I of the Vortex 42 Intrinsic neuronal oscillation together with sensory input is necessary for the modulation of ongoing movement. 12
Llinás; I of the Vortex 44 The spinal cord is capable of sustaining a rhythmic movement -- like a decapitated chicken -- but it cannot organize and generate a directed movement. 2
Llinás; I of the Vortex 44 Inferior Olive (IO) neurons play a fundamental role in movement coordination. 0
Llinás; I of the Vortex 46 Inferior olive IO neurons axons form nerve fiber bundles that route into the cerebellum.  2
Llinás; I of the Vortex 46 Purkinje cells are the largest nerve cells in the brain. 0
Llinás; I of the Vortex 46 Climbing fibers of IO axons climb up over the Purkinje cells' branching dendrites where the Purkinje cells receive input from other neurons. 0
Llinás; I of the Vortex 46 Most movement control processing occurs in the cerebellum. 0
Llinás; I of the Vortex 46 Climbing fibers, which are some of the most powerful synaptic inputs in the vertebrate central nervous system, play an important role in motor control. 0
Llinás; I of the Vortex 46 Purkinje cells are inhibitory onto  their target neurons. 0
Llinás; I of the Vortex 46 Axons of the  IO (inferior olive] cells give rise to the cerebellar climbing fibers. 0
Llinás; I of the Vortex 46 Transmembrane voltage in IO (inferior olive) cells oscillates spontaneously at 8-12 Hz. IO cells fire action potentials (spikes) at a frequency of  1-2 Hz, i.e., they do not fire on every oscillation.
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Llinás; I of the Vortex 46 IO cells (inferior olive) fire their action potentials rhythmically. Membrane conductance (ionic flow) underlies the generation of this oscillatory activity, which is referred to as regenerative firing. IO cells are capable of generating action potentials without excitatory input. 0
Llinás; I of the Vortex 48 Cerebellum is the neuronal area where most of the control of movement coordination is processed. 2
Llinás; I of the Vortex 48 Oscillation of the inferior olive results in a slight tremor at close to 10 Hz, even when we are not moving. 0
Llinás; I of the Vortex 48 The slight oscillatory movement (known as  physiological tremor) serves to time movements, like a metronome does when we are learning to play a musical instrument. 0
Llinás; I of the Vortex 48 No one can move faster than they can tremble.  0
Llinás; I of the Vortex 48 There is strong scientific evidence to indicate the relationship of the inferior olive to tremor. The pulsate organization of movement may well be related to rhythmic, ensemble output of the inferior olive.  0
Llinás; I of the Vortex 50 The brain's control of organized movement gave birth to the generation and nature of the mind.   [Fuster's  perception-action cycle] 2
Llinás; I of the Vortex 50 Most motor processing is handled by the cerebellum and its associated incoming and outgoing systems.  0
Llinás; I of the Vortex 50 Olivocerebellar system  is the prime candidate for a neural assembly capable of optimizing and simplifying motor control. 0
Llinás; I of the Vortex 55 Premotor template that serves as a planning platform for behavior or purposeful action.  [Fuster's  perception-action cycle] 5
Llinás; I of the Vortex 55 Regardless of training or personal effort, we cannot make movements faster than 10 Hz. 0
Llinás; I of the Vortex 56 Brain is a closed system modulated by the senses. 1
Llinás; I of the Vortex 57 Self-activating system is capable of emulating reality, even in the absence of input from reality, as occurs in dream states and daydreaming. 1
Llinás; I of the Vortex 57 Emotions are internally generated intrinsic events, excellent examples of premotor templates in primitive form. 0
Llinás; I of the Vortex 58 Play behavior by young animals is an exploration of internal functional space. 1
Llinás; I of the Vortex 63 Embryos generate continuous bouts of muscle tremor, not unlike small epileptic fits. 5
Llinás; I of the Vortex 63 Epileptic activity may be among the most primitive of all functional states -- a bit like sneezing. 0
Llinás; I of the Vortex 65 Transformations between sensory input and motor output is an internal functional space, which is made up of neurons that represent the properties of the external world.  [Fuster's  perception-action cycle] 2
Llinás; I of the Vortex 77 Phosphorus is critical to eukaryotic life. For energetically expensive tasks, cells must obtain the highest levels of usable energy from fuel molecules, via oxidative phosphorylation. 12
Llinás; I of the Vortex 77 With the development of calmodulin, the calcium/calmodulin complex became an intracellular tool as a signaling system via 'second messenger' roles. 0
Llinás; I of the Vortex 78 Neurons arose within the space between sensing and moving; this space evolved to become the brain. 1
Llinás; I of the Vortex 81 Neurons are a specialization of eukaryotic cells that allowed the evolution of natural 'computation' by cellular ensembles. 3
Llinás; I of the Vortex 82 Neurons came into existence to facilitate and orchestrate the ever-growing complexity of sensorimotor transformations. 1
Llinás; I of the Vortex 90 Electrochemical signaling, 1 to 5 milliseconds. 8
Llinás; I of the Vortex 90 Gap junction channels, direct flow of current from cell to cell, rapid and synchronous firing of interconnected cells. 0
Llinás; I of the Vortex 120 Temporal coherence - timeness is consciousness - perceptual unity based on spacial and temporal conjunction. 30
Llinás; I of the Vortex 124 Consciousness is a noncontinuous event determined by simultaneity of activity in the thalamocortical system. 4
Llinás; I of the Vortex 124 The 40-Hz oscillation is a candidate mechanism to produce temporal conjunction of rhythmic activity over a large ensemble of neurons. 0
Llinás; I of the Vortex 124 Thalamic input from the cortex is far larger than from the peripheral sensory systems. This suggests that thalamocortical iterative activity is a main mechanism of brain function.  [Fuster's  perception-action cycle] 0
Llinás; I of the Vortex 126 The thalamocortical system, by its hublike organization, allows radial communication of the thalamic nuclei with all aspects of the cortex. These cortical regions include the sensory, motor, and associational areas. These areas subserve a feedforward/feedback, reverberating flow of information.  [Fuster's  perception-action cycle] 2
Llinás; I of the Vortex 127 Prediction is the ultimate and most pervasive of all brain functions. 1
Llinás; I of the Vortex 128 "I" of the vortex 1
Llinás; I of the Vortex 128 Secondary qualities of our senses such as colors, identified smells, tastes, and sounds are but inventions/constructs of an intrinsic CNS (central nervous system) semantic. 0
Llinás; I of the Vortex 129 What distinction is there between dreaming and wakefulness? If cognition is a function of the 40-Hz thalamocortical resonance, what happens to this oscillatory rhythm during sleep, particularly dream or REM sleep? 1
Llinás; I of the Vortex 130 The 40-Hz coherent activity was present in the awake and REM sleep states, but greatly reduced in delta (slow-wave, deep sleep). 1
Llinás; I of the Vortex 130 An auditory stimulus produced 40-Hz oscillations in the wakefulness state 0
Llinás; I of the Vortex 130 The waking and REM sleep states are very similar with respect to the presence of 40-Hz oscillations. 0
Llinás; I of the Vortex 130 40-Hz oscillations are not reset by sensory input during REM sleep, even though studies have clearly shown that the thalamocortical system is accessible to sensory input during sleep. 0
Llinás; I of the Vortex 130 Difference between dreaming and wakefulness: the external world is not perceived during REM sleep because the intrinsic activity of the nervous system does not place sensory input within the context of the functional state being generated by the brain. 0
Llinás; I of the Vortex 131 Consciousness is a product of thalamocortical activity. 1
Llinás; I of the Vortex 131 Dialogue between the thalamus and the cortex generates subjectivity in humans and in higher vertebrates.  [Edelman's dynamic core] 0
Llinás; I of the Vortex 133 Fixed Action Patterns (FAPs)  -  Automatic brain modules that make complex movements; well defined motor patterns, (walking, swallowing) 2
Llinás; I of the Vortex 133 Compare FAPs, which include the brain, with spinal reflexes in which the brain is not involved. 0
Llinás; I of the Vortex 134 FAPs group simple reflexes and lower FAPs into functional modules capable of more complex goal-oriented behavior. 1
Llinás; I of the Vortex 134 Central Pattern Generators (CPGs) generate neuronal patterns of activity that drive FAPs such as the walking FAP. 0
Llinás; I of the Vortex 136 It is believed that the more complex FAPs are generated centrally by the basal ganglia. 2
Llinás; I of the Vortex 136 The basal ganglia represent some of the least understood areas of the brain, particularly in regard to their functional organization and architecture. 0
Llinás; I of the Vortex 136 Expression of FAPs is supported by the interplay among a number of vastly different parts of the nervous system and the basal ganglia. 0
Llinás; I of the Vortex 138 Majority of connections within the basal ganglia are inhibitory. 2
Llinás; I of the Vortex 138 Basal ganglia's intrinsic, reciprocal inhibitory activity keeps all potential FAPs from becoming active. 0
Llinás; I of the Vortex 138 When a FAP is executed, we say that it has been "liberated" into action. 0
Llinás; I of the Vortex 138 Basal ganglia are the doors that, when unlatched by the motor cortex, may release into action very large functions outside of the basal ganglia. 0
Llinás; I of the Vortex 144 FAPs are most probably implemented at the level of the basal ganglia and put into context by the reentry of the basal ganglia output into the ever-cycling thalamocortical system. 6
Llinás; I of the Vortex 151 Language itself is a FAP. 7
Llinás; I of the Vortex 151 Broca's area is responsible for the generation of motor aspects of language. 0
Llinás; I of the Vortex 152 Language centers of the brain - (diagram) 1
Llinás; I of the Vortex 152 Nervous system appears very much to be organized in functional modules. 0
Llinás; I of the Vortex 153 FAPS are subject to modification; they can be learned, remembered, and perfected. 1
Llinás; I of the Vortex 155 Emotions as Fixed Action Patterns (FAPs) 2
Llinás; I of the Vortex 156 Emotions are among the very oldest of our brain properties. 1
Llinás; I of the Vortex 157 Motor FAPs of relatively primitive animals are accompanied by a well-defined emotional component. 1
Llinás; I of the Vortex 161 Emotions are linked to the motor aspects of FAPs by access through the amygdala and the hypothalamus and their connectivity with the brain stem. 4
Llinás; I of the Vortex 164 A Parkinson patient cannot express the emotional state because their associated motor FAPs are no longer psychologically accessible. 3
Llinás; I of the Vortex 166 Macroscopic strategy of the brain -- smells awful, so don't eat it -- smells right, mate with it. 2
Llinás; I of the Vortex 168 Cognition and consciousness probably evolved from the emotional states that trigger FAPs. 2
Llinás; I of the Vortex 169 Combine FAPs, emotions, consciousness into one directed output -- Thalamocortical system. 1
Llinás; I of the Vortex 169 There is no perception that is ever separated from a possible, functional, motor implementation. 0
Llinás; I of the Vortex 169 Thalamocortical system, especially the non-specific intralaminar system, projects extremely aggressively to the basal ganglia. 0
Llinás; I of the Vortex 169 When a soloist plays a concerto with a symphony orchestra, the concerto is played purely from memory. This highly specific motor pattern FAP is stored somewhere in the brain during practice sessions and is released during the performance. 0
Llinás; I of the Vortex 169 Although it seems intuitively impossible that something as complicated and exacting in detail as the finger movements in playing Tchaikovsky's Violin Concerto would be a  FAP, it is an automatic module of discrete motor function. 0
Llinás; I of the Vortex 169 The playing of an instrumental concerto implies that a highly specific motor pattern is stored somewhere and subsequently released at the time of the performance. 0
Llinás; I of the Vortex 169 From the musical performance of an instrumental concerto example, it is evidence that a FAP can be learned.  In addition, a human FAP can be modified by experience. 0
Llinás; I of the Vortex 170 Neural processes underlying creativity have nothing to do with rationality. Creativity is not born out of reasoning. 1
Llinás; I of the Vortex 170 Activity in the basal ganglia is running all the time, playing motor patterns and snippets of motor patterns amongst and between themselves. Because of the reentrant inhibitory connectivity among and between these nuclei, they seem to act as a continuous, random, motor pattern generator. 0
Llinás; I of the Vortex 170 Mozart said his music came to him, uninterrupted. 0
Llinás; I of the Vortex 176 We are born with a well-wired brain and an incredible amount of knowledge derived from the genetic wiring of our brains. 6
Llinás; I of the Vortex 180 Some FAPs are critical for survival; begin breathing at birth. 4
Llinás; I of the Vortex 180 Certain emotional states are prewired and operative at birth. 0
Llinás; I of the Vortex 181 Referential memory represents that which has accrued during development and throughout a single lifetime.   [Autobiographical memory] 1
Llinás; I of the Vortex 182 Working memory -- (diagram) 1
Llinás; I of the Vortex 182 Working memory is the ability to hold the detail of significant content of the external world with the momentary internal context generated by the thalamocortical system. 0
Llinás; I of the Vortex 183 Coactivate familiar, associated patterns of already embedded patterns of activity. 1
Llinás; I of the Vortex 183 Pattern of ensemble firing in a given sensory cortex eventually associates and resonates with neurons in the cortical area that deal with related subjects. 0
Llinás; I of the Vortex 183 Particular snippet of a song is randomly released from the basal ganglia; this fragment of a FAP then brings with it the internal visual of when you heard this song last or perhaps where you were and what you were doing when you first heard it. 0
Llinás; I of the Vortex 184 Current event memory; no different from that used in remembering where you left the book you recently purchased. This memory may vanish in a few days. 1
Llinás; I of the Vortex 184 Memorable occasion; clearly referential; becomes transferred into long-term memory as "things we will never forget." 0
Llinás; I of the Vortex 184 Implicit memory 0
Llinás; I of the Vortex 184 Explicit memory 0
Llinás; I of the Vortex 185 Patient HM had surgery to control epilepsy; both medial temporal lobes removed in 1953; extensively studied aftermath. 1
Llinás; I of the Vortex 187 Neuroimaging, PET (positron emission tomography), fMRI (functional magnetic resonance imaging) 2
Llinás; I of the Vortex 187 Brain regions that seem to underlie implicit memory include the amygdala, whereas explicit memory involves the hippocampus and prefrontal cortex. 0
Llinás; I of the Vortex 188 Short-term or "working" memory is supported by ongoing activity that re-enters a neuronal loop. (analogous to continuously repeating a phone number while dialing), ongoing electrical activity produced by synaptic feedback. 1
Llinás; I of the Vortex 188 Donald O. Hebb 0
Llinás; I of the Vortex 188 Long Term Potentiation (LTP) 0
Llinás; I of the Vortex 193 Brain is prewired by nature and for the most part genetically determined. Hubel and Wiesel, vision; Mountcastle, somatosensory; Chomsky, language. 5
Llinás; I of the Vortex 194 Double vision (diplopia) occurs because the eyes are no longer perfectly aligned. 1
Llinás; I of the Vortex 194 Acquisition of phonemes that characterize a certain language; learned within a particular period of time; learn a particular language, but only at the expense of the ability to learn other languages. 0
Llinás; I of the Vortex 195 Limits of adaptability apply to everything we do or learn. 1
Llinás; I of the Vortex 199 Imprinting 4
Llinás; I of the Vortex 199 Neural resonance 0
Llinás; I of the Vortex 202 Primitive creatures such as ants and cockroaches are biological automatons. 3
Llinás; I of the Vortex 202 Brain function implements what natural selection has found to be the most beneficial in terms of species survivability. 0
Llinás; I of the Vortex 202 Sensory experience leading to active movement (motoricity) through the function of prediction is the ultimate reason for the very existence of the central nervous system.   [Fuster's  perception-action cycle] 0
Llinás; I of the Vortex 204 Epileptic patients, electrically stimulated cerebral cortex; limbs, finger, lips twitch from electrical stimulation of motor homunculus; sensory experiences elicited by electrical stimulation of somatosensory and association cortices. 2
Llinás; I of the Vortex 205 Somatosensory cortex ("sensory homunculus"), motor cortex ("motor homunculus"), Wilder Penfield maps. - (illustration) 1
Llinás; I of the Vortex 206 Qualia are fundamentally related to electrical activity in the brain. Qualia must be subserved by electrical events at nerve cells. 1
Llinás; I of the Vortex 206 A quantum of cognition is measured to be a well-defined 12-15 millisecond time epoch.    [This quantum of cognition has nothing to do with quantum mechanics.] 0
Llinás; I of the Vortex 206 The perceptual capability of the central nervous system is such that for two sensory stimuli to be perceived as two distinguishable sensory events, there must be a minimum of 12.5 milliseconds separating these events. 0
Llinás; I of the Vortex 206 A quantum of cognition requires the patterned activation of millions or even hundreds of millions of cells. 0
Llinás; I of the Vortex 207 Electricity is the only medium fast enough and far-reaching enough to support the rapid and widespread ensemble activity underlying sensory experience within perceptual time frames. 1
Llinás; I of the Vortex 207 In the deep sleep state, sensory input of all types (modalities) is for the most part rejected by the thalamocortical system. 0
Llinás; I of the Vortex 208 There are particular types of electrical patterns, global and local, that must be coactivated for feelings to be evoked. 1
Llinás; I of the Vortex 209 Some people believe that qualia represent very profound events in neuronal function dealing with quantum mechanical structures of neurons that include the detailed organization of microtubules and microfilaments. Llinás doubts that this topic is worth pursuing at any serious level. 1
Llinás; I of the Vortex 210 Patterned electrical activity in neurons and their molecular counterparts are sensations. 1
Llinás; I of the Vortex 210 Qualia or feelings - conscious experience. 0
Llinás; I of the Vortex 215 It is assumed that the brain attempts at all times to decrease the functional overhead of motor control. Further, it is assumed that the brain also attempts to decrease the functional overhead of sensory systems. 5
Llinás; I of the Vortex 215 We cannot experience everything all at once, all the time, so qualia provide a construct based on what the thalamocortical system deems worthy on a moment-to-moment basis of focus/attention/significance. 0
Llinás; I of the Vortex 215 Weber-Fechner law    governing the relationship between the intensity of sensory activation    and perception:    s = k * ln A/A0 0
Llinás; I of the Vortex 220 Generated from the internal functional geometry within the basal ganglia is a translation into expression through the functional geometry of how the body can and needs to move, given the momentary (internal and/or external) context. 5
Llinás; I of the Vortex 220 Functional organization of sensory systems, translation of the geometry of the properties of the external world into the geometry of the internal functional space, reality is that all times simplified. 0
Llinás; I of the Vortex 220 Think of qualia -- sensations or sensory experience -- as the brain's innate drive toward reducing overhead.  Each element of sensory input carries its own significance and the whole is assembled by the pre-existent presence of significant activity and the absence of other significant activity. 0
Llinás; I of the Vortex 221 Qualia as a sort of master organ, one that allows for the individual senses to operate or comingle in an ensemble fashion. 1
Llinás; I of the Vortex 228 Nervous system's capacity to generate the premotor imagery required to abstract the properties of things from the things themselves. 7
Llinás; I of the Vortex 228 Abstract thinking must have preceded language during evolution. 0
Llinás; I of the Vortex 228 Premotor events leading to expression of language are similar to the premotor events of any purposeful movement.  [Fuster's  perception-action cycle] 0
Llinás; I of the Vortex 229 Language exists in many species far older than Homo sapiens. 1
Llinás; I of the Vortex 229 Prosody is an outward gesturing of an internal state; smiling, laughter, frowning, lifting of one's eyebrows; convey internal state in a way that is recognizable to someone else. 0
Llinás; I of the Vortex 230 Prosody represents a subcategory within language. 1
Llinás; I of the Vortex 230 Pheromone delivery and reception systems of a moth are known to be effective for distances of several miles. Pheromone released by the female is recognized specifically and exclusively by the male of the same species; find each other in an otherwise crowded niche. 0
Llinás; I of the Vortex 237 FAP of vocalization. 7
Llinás; I of the Vortex 243 Vocalization became with usage a FAP. 6
Llinás; I of the Vortex 244 Wernicke's area (language comprehension, or auditory association area). 1
Llinás; I of the Vortex 244 Broca's speech area (alexia, inability to read, anomia, word-finding difficulties, aphasias, speech disorders). 0
Llinás; I of the Vortex