Squire;
Memory and Brain |
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Squire; Memory and Brain |
5 |
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Santiago Ramon y Cajal
(1852-1934) |
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Squire; Memory and Brain |
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Ivan P. Pavlov (1849-1936) |
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Squire; Memory and Brain |
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Aplysia californica (diagram) |
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Squire; Memory and Brain |
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Donald O. Hebb (1904-1985) |
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Squire; Memory and Brain |
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Schematic diagram of a synapse
onto a dendritic spine. (Diagram) |
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Long-term potentiation (LTP) |
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Squire; Memory and Brain |
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Developing nervous system.
Initial oversupply of cells and axon.
Neuronal death and the elimination of collateral branches of neurons. |
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In the projection from the lateral geniculate to visual cortex, synapse elimination is especially important in achieving
the adult pattern of connectivity |
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Pattern of arborization of a
single afferent axon in the visual cortex. (Diagram) |
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Changes that
result from visual
experience are
reflected directly in the morphology of the terminal fields of the competing axons. |
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Squire; Memory and Brain |
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Competition
is most likely a prominent event in the adult nervous system, long after development is
complete. |
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Hebb synapse plasticity -- synaptic efficacy would increase between the input cell and a postsynaptic cell in situations
where the input successfully fires the postsynaptic cell. |
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Effects of experience on the functional connectivity of neural pathways are reflected in morphological change, which
depends upon the degree of activity and synchrony in the inputs converging on common targets. |
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Squire; Memory and Brain |
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Remembering
and forgetting. |
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Squire; Memory and Brain |
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Forgetting
involves actual loss of some of the neural
connections that originally
represented acquired information. |
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Information
in long-term memory eventually becomes resistant to
forgetting. |
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All forgetting, whether it occurs in a few hours or over a period of years,
reflects in part an actual loss of information from storage and a corresponding regression of some of the synaptic changes that originally
represented the stored information. |
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Squire; Memory and Brain |
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The forebrain in general and neocortex in particular are innervated extrinsically and by several
separate, widely projecting ascending fiber systems, each of them linked to a
particular neurotransmitter. |
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Squire; Memory and Brain |
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Cortical norepinephrine
(NE) originates in the
locus coeruleus, a small nucleus in the brainstem at the level of the pons
that contains only an estimated 9000 to 16,000
cells in the adult
human. |
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Locus coeruleus slow conducting axons connect with a number of regions in
the brain, notably amygdala, hippocampus,
hypothalamus, and thalamus. |
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Locus coeruleus is believed to be the only source of NE fibers for most of the forebrain. |
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Widely projecting modulatory
systems. |
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Locus coeruleus neurons, the source of the forebrain
NE system, fire in
relation to the animal's level of vigilance. |
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Set of changes in the nervous
system that represents stored memory is commonly known as the engram. |
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Memory for whole events is
stored widely, not in a single location. Recollection of past events is a
reconstruction from fragments, not a veridical playback of past events. |
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Squire; Memory and Brain |
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Little reason to postulate more
than two stages of memory, short-term and long-term. |
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Information in long-term memory
continues to change for many years. Some or all of it can become independent
of the medial temporal region (hippocampus). |
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Certain short-term forms of
synaptic plasticity do not require protein synthesis. |
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Long-term memory requires the
participation of the medial temporal region, which operates in conjunction
with the assemblies of neurons that represent stored information. |
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Synaptic plasticity describes a
variety of phenomena with different time courses, such as facilitation,
post-tetanic potentiation, and long-term potentiation. |
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Declarative memory is memory that is directly
accessible to conscious
recollection. |
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Procedural memory is memory that is contained within
learned skills or modifiable
cognitive operations. [Stereotyped motor programs] [FAPs] |
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Priming is the facilitation of
performance by prior exposure to words or other material. This facilitation
occurs despite impared recall or recognition of the same material. |
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Priming effects are spared in amnesia. |
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The terms 'declarative'
and 'procedural' first appeared in the literature of artificial intelligence (1975) and cognitive psychology (1976). |
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Priming is
a short-lived
phenomenon. |
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Declarative memory is fast,
adaptive for one-trial learning. In contrast, procedural memory is slow, more automatic, adaptive for
incremental learning. |
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Procedural memory is not a
single thing. Procedural
memory Includes motor
skill learning, cognitive skill learning, perceptual learning, classical
conditioning, as well as simpler examples of behavioral plasticity such as habituation, sensitization, and
perceptual after-effects. |
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Classical conditioning of skeletal musculature depends at least in part on neural
pathways in the cerebellum. |
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Declarative memory may prove to be a relatively recent evolutionary
innovation. |
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The specific tightly wired,
limited access machinery in the brain
the cognitive unconscious. [Stereotyped motor
programs] [FAPs] |
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Medial temporal region and associated structures of affording animals the capacity
for declarative memory. |
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Declarative memory can be further subdivided into
'episodic' and
'semantic' memory. |
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Episodic memory a reversion memory for past events and an individual's life. |
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Semantic memory refers to knowledge of the world. This system represents organized
information such as facts, concepts, and vocabulary. |
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Unlike episodic memory, semantic memory has no necessary
temporal landmarks. |
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Declarative memory includes what can be declared or brought to mind as a
proposition or an image. |
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Procedural memory includes motor skills, cognitive skills, simple classical conditioning, habituation, sensitization, and other cognitive operations improved by experience. |
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Amnesic patients can normal
immediate memory and also normal remote memory. |
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Medial temporal amnesia. |
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Patient H.M. |
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Section through the temporal
lobe of a normal human brain, showing subicular cortex, presubiculum,
subiculum, CA subfields of the hippocampal formation, dentate gyrus. -
(photo) |
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Both the hippocampus and the amygdala receive information from sensory-specific cortical areas and
from multimodal association areas. |
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Fornix is
only one of two major efferent
pathways from the hippocampus. |
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Aging and memory. |
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Amnesic patients are normal at
object-naming tests. |
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Amnesia and the functional
organization of memory. |
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In amnesia, general intellectual ability is intact; short-term memory is intact. |
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Within the domain of declarative memory, medial temporal
structures are
involved only in the establishment and consolidation of long-term
memory, not short-term |
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Consolidation
refers to the ideas that memory storage does not occur instantaneously but
instead develops gradually after Initial learning. |
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Neural elements and the synaptic
connectivity representing information storage are presumed to change
gradually over time. |
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Squire; Memory and Brain |
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Consolidation
is a competitive process in which some aspects of memory for the original event are
forgotten, while those that remain are strengthened. |
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Consolidation
is a process that occurs within the collection of
distributed sites where
synaptic change representing information storage has occurred. |
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Electroconvulsive therapy (ECT) for depressive illness. |
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Retrograde amnesia following medial terminal lobe
damage suggests that at
the time of learning, the medial temporal region establishes a functional
relationship with memory
storage sites, especially in neocortex. |
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Hippocampal formation can
exhibit to long-lasting synaptic change in response to brief, high-frequency
stimulation of its input pathway (long-term potentiation, or LTP). |
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LTP could be one index of the
relationship between hippocampus and neocortex. |
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Memory and Brain |
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During the lengthy process of consolidation, the critical neural
system within the medial temporal region may maintain the organization of distant memory storage sites, until such time as the coherence
of these sites increases and they can be activated as an ensemble without the participation of the medial temporal region. [Gestalts] |
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Memory
depends on the interaction between a specialized system within the medial temporal region and memory storage sites in neocortex. |
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Squire; Memory and Brain |
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Patients with alcoholic
Korsakoff's syndrome commonly have damage to
brain stem, cerebellum, and neocortex in addition to specific diencephalic
lesions. |
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Patients with Korsakoff's
syndrome exhibit a severe deficit in remembering
the temporal order of learned items. |
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Inferotemporal cortex is presumed to both process and store information about the identity of visual objects. |
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